| pubmed-article:6425482 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6425482 | lifeskim:mentions | umls-concept:C0184511 | lld:lifeskim |
| pubmed-article:6425482 | lifeskim:mentions | umls-concept:C0015506 | lld:lifeskim |
| pubmed-article:6425482 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:6425482 | lifeskim:mentions | umls-concept:C0472801 | lld:lifeskim |
| pubmed-article:6425482 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:6425482 | lifeskim:mentions | umls-concept:C0701195 | lld:lifeskim |
| pubmed-article:6425482 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:6425482 | pubmed:dateCreated | 1984-6-7 | lld:pubmed |
| pubmed-article:6425482 | pubmed:abstractText | We studied the differential increase in FVIIIc and FVIII R:Ag after the intravenous infusion of 0.30 micrograms/kg DDAVP in 20 obligate hemophilia A carriers and in 20 female controls. FVIIIc increased in carriers (59.5 +/- 23.1 to 137.5 +/- 45.9) and in controls (98.0 +/- 20.7 to 259.9 +/- 57.4) (P less than 0.001), but the magnitude of the FVIIIc increase in carriers was less than that in controls by 51.9% (P less than 0.001). FVIII R:Ag increased comparably in carriers (105.2 +/- 30.4 to 171.9 +/- 25.4) and controls (92.1 +/- 33.0 to 165.2 +/- 20.6). Using the post-DDAVP instead of the standard FVIIIc/FVIII R:Ag ratio, hemophilia carrier detection was increased from 85% (with 10% false positive and 20% false negative assignments) to 95% (with 5% false positive and 5% false negative assignments). Toxicity associated with DDAVP infusion correlated linearly with doses greater than 10.5 +/- 1.3 micrograms/m2 (P less than 0.02) and with total doses greater than 17.0 +/- 4.5 micrograms (P less than 0.02). The use of DDAVP improves carrier detection in factor VIII-deficient hemophilia. | lld:pubmed |
| pubmed-article:6425482 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6425482 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6425482 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6425482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6425482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6425482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6425482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6425482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6425482 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6425482 | pubmed:month | May | lld:pubmed |
| pubmed-article:6425482 | pubmed:issn | 0022-3476 | lld:pubmed |
| pubmed-article:6425482 | pubmed:author | pubmed-author:WatsonC MCM | lld:pubmed |
| pubmed-article:6425482 | pubmed:author | pubmed-author:KobrinskyN... | lld:pubmed |
| pubmed-article:6425482 | pubmed:author | pubmed-author:BishopA JAJ | lld:pubmed |
| pubmed-article:6425482 | pubmed:author | pubmed-author:CheangM SMS | lld:pubmed |
| pubmed-article:6425482 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6425482 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:6425482 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6425482 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6425482 | pubmed:pagination | 718-24 | lld:pubmed |
| pubmed-article:6425482 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:6425482 | pubmed:meshHeading | pubmed-meshheading:6425482-... | lld:pubmed |
| pubmed-article:6425482 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6425482 | pubmed:articleTitle | Improved hemophilia A carrier detection by DDAVP stimulation of factor VIII. | lld:pubmed |
| pubmed-article:6425482 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6425482 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
