|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1984-6-7
|
|
pubmed:abstractText |
We studied the differential increase in FVIIIc and FVIII R:Ag after the intravenous infusion of 0.30 micrograms/kg DDAVP in 20 obligate hemophilia A carriers and in 20 female controls. FVIIIc increased in carriers (59.5 +/- 23.1 to 137.5 +/- 45.9) and in controls (98.0 +/- 20.7 to 259.9 +/- 57.4) (P less than 0.001), but the magnitude of the FVIIIc increase in carriers was less than that in controls by 51.9% (P less than 0.001). FVIII R:Ag increased comparably in carriers (105.2 +/- 30.4 to 171.9 +/- 25.4) and controls (92.1 +/- 33.0 to 165.2 +/- 20.6). Using the post-DDAVP instead of the standard FVIIIc/FVIII R:Ag ratio, hemophilia carrier detection was increased from 85% (with 10% false positive and 20% false negative assignments) to 95% (with 5% false positive and 5% false negative assignments). Toxicity associated with DDAVP infusion correlated linearly with doses greater than 10.5 +/- 1.3 micrograms/m2 (P less than 0.02) and with total doses greater than 17.0 +/- 4.5 micrograms (P less than 0.02). The use of DDAVP improves carrier detection in factor VIII-deficient hemophilia.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0022-3476
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
104
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
718-24
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:6425482-Adolescent,
pubmed-meshheading:6425482-Adult,
pubmed-meshheading:6425482-Analysis of Variance,
pubmed-meshheading:6425482-Antigens,
pubmed-meshheading:6425482-Arginine Vasopressin,
pubmed-meshheading:6425482-Child,
pubmed-meshheading:6425482-Deamino Arginine Vasopressin,
pubmed-meshheading:6425482-Drug Evaluation,
pubmed-meshheading:6425482-Factor VIII,
pubmed-meshheading:6425482-False Negative Reactions,
pubmed-meshheading:6425482-False Positive Reactions,
pubmed-meshheading:6425482-Female,
pubmed-meshheading:6425482-Headache,
pubmed-meshheading:6425482-Hemophilia A,
pubmed-meshheading:6425482-Heterozygote Detection,
pubmed-meshheading:6425482-Humans,
pubmed-meshheading:6425482-Male,
pubmed-meshheading:6425482-Middle Aged,
pubmed-meshheading:6425482-von Willebrand Factor
|
|
pubmed:year |
1984
|
|
pubmed:articleTitle |
Improved hemophilia A carrier detection by DDAVP stimulation of factor VIII.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
