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rdf:type |
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lifeskim:mentions |
umls-concept:C0021745,
umls-concept:C0030685,
umls-concept:C0040671,
umls-concept:C0391871,
umls-concept:C0591833,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1515877,
umls-concept:C1516240,
umls-concept:C1521761,
umls-concept:C1879547,
umls-concept:C1963578
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pubmed:issue |
5
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pubmed:dateCreated |
1984-6-18
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pubmed:abstractText |
In this report we demonstrate that when the murine macrophage tumor cell line P- 388D1 is incubated for 48-72 h with either concanavalin A-stimulated rat spleen cell supernatant or cloned murine immune interferon (IFN-gamma), the cultured cells release a cell-free factor activity that in turn induces the cell surface expression of Ia antigen on the murine monocyte cell line WEHI-3. This IFN-gamma-stimulated, Ia-inducing activity cannot be blocked with an anti-IFN-gamma heteroantiserum that does block the induction of Ia expression on WEHI-3 by both cloned murine IFN-gamma and rat Con A supernatant. The Ia-inducing factor ( IaIF ) generated from P- 388D1 after stimulation by IFN-gamma does not demonstrate any antiviral activity. The P- 388D1 -derived IaIF is not shed plasma membrane Ia glycoprotein molecules, as demonstrated by the inability of the active component to bind specifically to an anti-I-Ad affinity column or to a protein A column after the active supernatant is first treated with an excess of anti-I-E/Cd,k monoclonal antibody.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-112037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-1167564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-145543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-198670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-214520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-30693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-313896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-349081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-448069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-448081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-448116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-5259325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-6166712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-6173461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-6192500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-6287286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-6310596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-6408177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-6408189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-6448907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-6450260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-6571711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-6797272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-6816896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-6976995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-7033383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6425449-89077
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
159
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1532-47
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6425449-Animals,
pubmed-meshheading:6425449-Antibodies,
pubmed-meshheading:6425449-Antigens, Surface,
pubmed-meshheading:6425449-Antiviral Agents,
pubmed-meshheading:6425449-Binding, Competitive,
pubmed-meshheading:6425449-Cell Line,
pubmed-meshheading:6425449-Chromatography, Affinity,
pubmed-meshheading:6425449-Chromatography, Agarose,
pubmed-meshheading:6425449-Concanavalin A,
pubmed-meshheading:6425449-Flow Cytometry,
pubmed-meshheading:6425449-Histocompatibility Antigens Class II,
pubmed-meshheading:6425449-Interferon-gamma,
pubmed-meshheading:6425449-Lymphocyte Cooperation,
pubmed-meshheading:6425449-Lymphokines,
pubmed-meshheading:6425449-Macrophage Activation,
pubmed-meshheading:6425449-Macrophage-Activating Factors,
pubmed-meshheading:6425449-Macrophages,
pubmed-meshheading:6425449-Mice,
pubmed-meshheading:6425449-Rats
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pubmed:year |
1984
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pubmed:articleTitle |
Murine gamma interferon activates the release of a macrophage-derived Ia-inducing factor that transfers Ia inductive capacity.
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pubmed:publicationType |
Journal Article
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