Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1984-6-7
|
| pubmed:abstractText |
The mutant allele giant of Drosophila melanogaster affects the timing and the level of increase in ecdysteroid titer normally occurring at puparium formation. The third larval instar is extended by 4 days in phenotypically "giant" individuals during which the imaginal discs mature slower than normal and finally take on the folding pattern characteristic of maturity at a time when normal individuals have already formed puparia. After puparium formation, development occurs at the same rate in giant and wild-type animals. Feeding 20-hydroxyecdysone at 94 hr after oviposition allows giant larvae to develop at the same rate as wild-type larvae and to produce normal-sized adults (although at 94 hr the imaginal discs of giant lack much of the folding pattern of mature discs). Radioimmunological determination of ecdysteroid titers in giant and normal individuals indicates that the peak of ecdysteroid activity associated with puparium formation is lower in giant and occurs 4 days later than normal. These results indicate that giant is an ecdysteroid-deficient mutant with major effects on metamorphosis. Unlike previously reported ecdysteroid-deficient mutants, however, giant larvae eventually develop into adults and may be induced to undergo complete metamorphosis at the same time as wild type by feeding 20-hydroxyecdysone.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0012-1606
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
103
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
85-95
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:6425099-Alleles,
pubmed-meshheading:6425099-Animals,
pubmed-meshheading:6425099-Chromosome Deletion,
pubmed-meshheading:6425099-Drosophila melanogaster,
pubmed-meshheading:6425099-Ecdysteroids,
pubmed-meshheading:6425099-Invertebrate Hormones,
pubmed-meshheading:6425099-Larva,
pubmed-meshheading:6425099-Metamorphosis, Biological,
pubmed-meshheading:6425099-Mutation,
pubmed-meshheading:6425099-Pupa
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Analysis of metamorphosis in Drosophila melanogaster: characterization of giant, an ecdysteroid-deficient mutant.
|
| pubmed:publicationType |
Journal Article
|