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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1984-5-11
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pubmed:abstractText |
A new, sensitive, and specific high-performance liquid chromatographic method for the quantitative analysis of [14C]glyceryl trinitrate and its four metabolites in plasma is described. The drugs are extracted from 0.05 ml of plasma with methanol and analyzed by high-performance liquid chromatography using a synchronized accumulating radioisotope detector. The limit of detection is 0.2 ng per injection. The within-day coefficient of variation is 5.9% at a concentration of 27.0 ng per ml of plasma. The method was applied to single-dose pharmacokinetics of glyceryl trinitrate in rat.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-9673
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
305
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
119-26
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:6423655-Animals,
pubmed-meshheading:6423655-Carbon Radioisotopes,
pubmed-meshheading:6423655-Chromatography, High Pressure Liquid,
pubmed-meshheading:6423655-Half-Life,
pubmed-meshheading:6423655-Injections, Intravenous,
pubmed-meshheading:6423655-Kinetics,
pubmed-meshheading:6423655-Male,
pubmed-meshheading:6423655-Nitroglycerin,
pubmed-meshheading:6423655-Rats,
pubmed-meshheading:6423655-Rats, Inbred Strains
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pubmed:year |
1984
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pubmed:articleTitle |
Application of high-performance liquid chromatography with synchronized accumulating radioisotope detector to analysis of glyceryl trinitrate and its metabolites in rat plasma.
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pubmed:publicationType |
Journal Article
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