Linked Life Data

6422585

Source:http://linkedlifedata.com/resource/pubmed/id/6422585

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-4-24
pubmed:abstractText
Female rhesus monkeys (24) were divided into 3 groups and fed diets calculated to contain 1.0, 0.25 or 0 parts per million (ppm) of a commercial mixture of polychlorinated biphenyls (PCBs), Aroclor 1016. The animals consumed a calculated total of 18.1 +/- 3.1, 4.5 +/- 0.6 and 0 mg Aroclor 1016/kg of body weight over the 87 +/- 9 week experimental period. All animals were bred, conceived and experienced uncomplicated pregnancies. The birth weights of the infants born to females receiving the 1.0 ppm PCB diets were significantly less than those of the control infants. There was a positive relationship between the levels of Aroclor 1016 in the tissues and the dose administered in the diets. Aroclor 1016 content of infant tissues was consistent with maternal adipose tissue PCB levels. The content of Aroclor 1016 in the milk fat of the animals more closely approximated that in the individual's adipose tissue than in the serum. At weaning, the mesenteric fat of the experimental infants contained concentrations of Aroclor 1016 which were 4-7 times that found in the mothers. Analyses of the tissues and fluids of the experimental animals demonstrated accumulation of PCB isomerides. The number of isomerides present and the ratio of those detected differed between adult and infants as well as between milk and serum. After weaning, the pattern of Aroclor 1016 isomerides present in the infants' adipose was similar to that observed at weaning although the concentrations had decreased.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0300-483X
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
31-44
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Accumulation of a commercial polychlorinated biphenyl mixture (Aroclor 1016) in adult rhesus monkeys and their nursing infants.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.