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pubmed:abstractText |
Ionophore A23187, an agent that promoves Ca2+ influx into cells, significantly increases enzymatic leakage of AST and LDH into the medium by perfused rat livers. This work provides evidence that Ca2+ dependent hepatotoxicity can be studied conveniently in vitro whit isolated and perfused rat livers, since this model respects integrity of organ and duplicates many its in vivo functions.
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