Linked Life Data

6420209

Source:http://linkedlifedata.com/resource/pubmed/id/6420209

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1984-3-23
pubmed:abstractText
TRH tests (500 micrograms, i.v. bolus) were performed in 15 patients with various hypothalamic or pituitary disorders and in 6 control subjects. TSH (highly sensitive RIA) and T3 were measured before and 30, 60, 90 and 120 min. after TRH. In 8 out of 15 patients, low circulating thyroid hormone levels were observed, but their basal TSH levels were all in the normal range or even higher (0.8 - 5.5 microU/ml). Further, their integrated TSH responses (38 +/- 21 microU/ml) did not differ significantly from those of control group (35 +/- 16 microU/ml). Except for 2 cases with hypothalamic hypothyroidism, T3 increments after TRH were found consistently lower than 5 ng/dl in these hypothyroid patients. One of them revealed significant elevations of T3, T4 and thyroid 99mTc-pertechnetate uptake after 5 I.U. x 2 i.m. bovine TSH. In 19 cases studied (2 cases with hypothalamic hypothyroidism were omitted), basal T3 levels were found to show quite a good correlation (r = 0.738) with T3 increments after TRH. Therefore, TSH values by radioimmunoassay in hypothalamo-pituitary disorders were considered not relevant to be the levels of a real thyroid stimulator, or they seemed to contain biologically inactive moieties. In conclusion, measurement of the TSH level and even the TRH-TSH test were found unreliable in diagnosing central hypothyroidism, and the TRH-T3 test appeared to give quite useful diagnostic information.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0029-0661
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1131-7
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
[Usefulness of the TRH-T3 test in the diagnosis of central hypothyroidism].
pubmed:publicationType
Journal Article, English Abstract