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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1984-3-19
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pubmed:abstractText |
Methods for determining Ro 15-1788 in brain tissue were developed using gas chromatography with nitrogen-phosphorus detection, and using reverse-phase high performance liquid chromatography. Application of the methods to pharmacokinetic studies in the rat found the elimination half-life of Ro 15-1788 from rat brain to be 16 min. Ro 15-1788 was undetectable in rat plasma at the time points studied. Concentrations of Ro 15-1788 in the brain were reduced if chlordiazepoxide was coadministered.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
290
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
183-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:6419985-Animals,
pubmed-meshheading:6419985-Anti-Anxiety Agents,
pubmed-meshheading:6419985-Benzodiazepines,
pubmed-meshheading:6419985-Benzodiazepinones,
pubmed-meshheading:6419985-Brain,
pubmed-meshheading:6419985-Brain Chemistry,
pubmed-meshheading:6419985-Chlordiazepoxide,
pubmed-meshheading:6419985-Flumazenil,
pubmed-meshheading:6419985-Half-Life,
pubmed-meshheading:6419985-Kinetics,
pubmed-meshheading:6419985-Male,
pubmed-meshheading:6419985-Rats
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pubmed:year |
1984
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pubmed:articleTitle |
Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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