Linked Life Data

6419236

Source:http://linkedlifedata.com/resource/pubmed/id/6419236

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-2-14
pubmed:abstractText
To investigate the relationship between development of autoimmune disease and arachidonic acid metabolism, we compared lipoxygenase and cyclooxygenase activities of lymphoid cells in MRL/1 mice during the development of the disease. Lipoxygenase activity per cell of lymph mo mice, although cyclooxygenase activity was low in both cases. These phenomena did not depend on aging since age-matched MRL/n mice lacking the lpr gene (congenic with MRL/1 mice), and BALB/c mice did not exhibit any change in the enzyme activity with aging. The lipoxygenase activity of 4 mo MRL/1 lymph node cells came mainly from nylon wool nonadherent cells. Lipoxygenase activity of nylon wool nonadherent spleen cells in MRL/1 mice was also higher in 4 mo mice than that in 1.5 mo mice, whereas we could not detect any difference in nylon wool adherent cells. The major lipoxygenase product was 12-hydroxyeicosatetraenoic acid (12-HETE), which was identified by a high performance liquid chromatography (HPLC). Our data suggest that change in arachidonic acid metabolism in T cells may be related to development of autoimmune disease in MRL/1.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0262-1746
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Augmentation of 12-lipoxygenase activity of lymph node and spleen T cells in autoimmune mice MRL/1.
pubmed:publicationType
Journal Article, Comparative Study