Linked Life Data

6413693

Source:http://linkedlifedata.com/resource/pubmed/id/6413693

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1983-11-23
pubmed:abstractText
In aqueous solution and using molecular oxygen as electron acceptor, the antitumor drug 9-hydroxyellipticine (9-OH-E) undergoes a spontaneous oxidation to give hydrogen peroxide (H2O2), the quinone imine 9-oxoellipticine (9-oxo-E), and a dimer of 9-OH-E(9-OH-E2). Electron paramagnetic resonance (EPR) experiments performed either in alkaline Me2SO or in phosphate buffer in the presence of the spin trap 5,5-dimethylpyrroline 1-oxide (DMPO) suggest that the oxidation process involves the initial formation of superoxide anion (O2- .) and the free radical of the drug. In aqueous medium, this step is followed by the dismutation of both O2- . and free radicals of the drug generating, respectively, H2O2 and 9-oxo-E. 9-Oxo-E further reacts with the 9-OH-E remaining in the solution to form the dimer 9-OH-E2 as the terminal product. The autoxidation process is strongly enhanced by superoxide dismutase and manganese ions. In the ellipticine series, all drugs that have an OH group in position 9 exhibit the ability to transfer one electron on molecular oxygen to generate O2- .. This property may be involved in the cytotoxic activities of these drugs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1438-44
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Autoxidation of the antitumor drug 9-hydroxyellipticine and its derivatives.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't