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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1983-11-23
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pubmed:abstractText |
The primary translation product of the mRNA for rabbit haptoglobin was obtained from a rabbit reticulocyte lysate cell-free system by immunoprecipitation with an antiserum that was directed to the beta chain of haptoglobin. Analysis of the translation product by gel electrophoresis and by protein sequencing analysis identified a single polypeptide of Mr 41 000. Sequence analysis established a signal region of 18 residues that was immediately followed by the alpha chain sequence. These results give strong evidence that haptoglobin is initially synthesized as a single chain composed of a signal peptide followed by alpha and beta chain regions, respectively.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-5793
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
153
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
275-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6413248-Amino Acid Sequence,
pubmed-meshheading:6413248-Animals,
pubmed-meshheading:6413248-Haptoglobins,
pubmed-meshheading:6413248-Immunodiffusion,
pubmed-meshheading:6413248-Molecular Weight,
pubmed-meshheading:6413248-Protein Biosynthesis,
pubmed-meshheading:6413248-RNA, Messenger,
pubmed-meshheading:6413248-Rabbits,
pubmed-meshheading:6413248-Reticulocytes
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pubmed:year |
1983
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pubmed:articleTitle |
Biosynthesis of rabbit haptoglobin: chemical evidence for a single chain precursor.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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