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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1983-10-8
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pubmed:abstractText |
2'-O-methyladenosine (Am) specifically inhibits growth of vaccinia virus on cultured monkey kidney (BSC40) cells. Specificity has been demonstrated by the isolation of an Am-resistant mutant of vaccinia which forms plaques on Am-treated monolayers of BSC40 cells under conditions where wild type (wt) plaque formation is inhibited. Am inhibits virus growth at an early stage of infection; host shut off and early virus protein synthesis are inhibited by the drug.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0042-6822
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
30
|
pubmed:volume |
128
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
458-62
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:6412452-Adenosine,
pubmed-meshheading:6412452-Animals,
pubmed-meshheading:6412452-Cell Line,
pubmed-meshheading:6412452-Drug Resistance, Microbial,
pubmed-meshheading:6412452-Genes, Viral,
pubmed-meshheading:6412452-Haplorhini,
pubmed-meshheading:6412452-Mutation,
pubmed-meshheading:6412452-Vaccinia virus,
pubmed-meshheading:6412452-Viral Plaque Assay,
pubmed-meshheading:6412452-Viral Proteins,
pubmed-meshheading:6412452-Virus Replication
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pubmed:year |
1983
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pubmed:articleTitle |
Specific inhibition of vaccinia virus growth by 2'-O-methyladenosine: isolation of a drug-resistant virus mutant.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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