Linked Life Data

6411351

Source:http://linkedlifedata.com/resource/pubmed/id/6411351

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-10-8
pubmed:databankReference
pubmed:abstractText
Analysis of mouse cDNA clones has led to the identification of a class I (H-2)-related gene that encodes a truncated transplantation-like antigen. Unlike the products of the class I genes (H-2K, H-2D, and H2-L), which are synthesized and displayed on the surface of all cells, the class I-related gene product is expressed only in liver cells and is secreted. The region of the secreted molecule corresponding to the extracellular domain of the membrane-bound class I antigens shows unusual amino acid substitutions at positions otherwise invariably conserved. There is also loss of a glycosylation site that is used in all class I antigens. Within the region corresponding to the transmembrane domain are multiple nonconservative substitutions of hydrophobic residues, alterations that render the encoded protein incapable of inserting into the plasma membrane. Toward the end of the same domain, the polypeptide chain terminates abruptly and thus lacks the intracellular domain present on all class I antigens. A candidate for this secreted molecule, detected using various heteroantisera against class I antigens, has been identified. A potential role for this serum protein in mediating active tolerance is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
189-96
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Secretion of a transplantation-related antigen.
pubmed:publicationType
Journal Article, Comparative Study