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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1983-9-20
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pubmed:abstractText |
Opening of the blood-brain barrier after intravenous injection of different contrast media has been investigated by a quantitative autoradiographic technique using 14C-aminoisobutyric acid (AIB) as the blood-brain barrier radiotracer. In this study, experiments were carried out in adult rats. Animals were injected intravenously with 2 ml/kg of the tested contrast medium, and immediately afterward with the blood-brain radiotracer AIB. The following contrast media have been tested: diatrizoate 38%, ioxithalamate 38%, ioxaglate 38%, the nonionic product metrizamide 40%, and a new nonionic product P-297, 400 mg l/ml. Control animals were injected intravenously with saline 0.9% (2 ml/kg) before the injection of the tracer. The degree of blood-brain barrier opening was quantitatively assessed by calculating the capillary rate constant for blood-to-brain transfer of AIB (ki) from the brain activity and the arterial integral for a 6 min experiment. Preliminary data seem to indicate that the intravenous injection of 2 ml/kg of a constant medium may produce a tiny opening of the blood-brain barrier. But, if this is so, this blood-brain barrier opening is of a very low magnitude in the normal brain and there are no obvious differences between the test contrast agents injected intravenously.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Contrast Media,
http://linkedlifedata.com/resource/pubmed/chemical/Diatrizoate,
http://linkedlifedata.com/resource/pubmed/chemical/Iothalamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Ioxaglic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Metrizamide,
http://linkedlifedata.com/resource/pubmed/chemical/P297,
http://linkedlifedata.com/resource/pubmed/chemical/Triiodobenzoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/ioxitalamic acid
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pubmed:status |
MEDLINE
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pubmed:issn |
0195-6108
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
323-5
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pubmed:dateRevised |
2008-2-14
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pubmed:meshHeading |
pubmed-meshheading:6410734-Animals,
pubmed-meshheading:6410734-Autoradiography,
pubmed-meshheading:6410734-Blood-Brain Barrier,
pubmed-meshheading:6410734-Contrast Media,
pubmed-meshheading:6410734-Diatrizoate,
pubmed-meshheading:6410734-Iothalamic Acid,
pubmed-meshheading:6410734-Ioxaglic Acid,
pubmed-meshheading:6410734-Metrizamide,
pubmed-meshheading:6410734-Rats,
pubmed-meshheading:6410734-Triiodobenzoic Acids
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pubmed:articleTitle |
Autoradiographic method for quantitative evaluation of the blood-brain barrier effects of contrast media.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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