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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1983-9-9
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pubmed:abstractText |
Endotoxic shock was induced in rabbits of either sex by IV injection of 50 micrograms/kg endotoxin (ET) extracted from E coli O-55 by Boivin's method. A polyvinyl catheter was introduced into the superior vena cava under local anesthesia 1 day prior to the experiments. We observed a rise of plasma-free fatty acids (FFA) from an initial mean value of 190 muEq/liter to a level of 290 muEq/liter within 6 h after injection of endotoxin. The increase of FFA was followed by a rise of plasma triglycerides (TG) and an increase of very low-density lipoproteins (VLDL), beginning 1-2 h later. The rise of FFA and the following increase of TG and VLDL were significantly reduced by infusion of 14 micrograms/kg X min gabexate mesilate (GM). Our results indicate that GM--in addition to its well-known proteinase inhibitory action--effects fatty acid metabolism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0195-878X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
43-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:6410701-Animals,
pubmed-meshheading:6410701-Arrhythmias, Cardiac,
pubmed-meshheading:6410701-Endotoxins,
pubmed-meshheading:6410701-Fatty Acids, Nonesterified,
pubmed-meshheading:6410701-Female,
pubmed-meshheading:6410701-Gabexate,
pubmed-meshheading:6410701-Glycerol,
pubmed-meshheading:6410701-Guanidines,
pubmed-meshheading:6410701-Lipoproteins, VLDL,
pubmed-meshheading:6410701-Male,
pubmed-meshheading:6410701-Rabbits,
pubmed-meshheading:6410701-Shock, Septic,
pubmed-meshheading:6410701-Triglycerides
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pubmed:year |
1983
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pubmed:articleTitle |
Effects of gabexate mesilate on the reactions of lipid metabolism in endotoxic shock.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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