| pubmed-article:6409093 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6409093 | lifeskim:mentions | umls-concept:C0026030 | lld:lifeskim |
| pubmed-article:6409093 | lifeskim:mentions | umls-concept:C0027303 | lld:lifeskim |
| pubmed-article:6409093 | lifeskim:mentions | umls-concept:C0027310 | lld:lifeskim |
| pubmed-article:6409093 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:6409093 | lifeskim:mentions | umls-concept:C0034580 | lld:lifeskim |
| pubmed-article:6409093 | lifeskim:mentions | umls-concept:C0449851 | lld:lifeskim |
| pubmed-article:6409093 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6409093 | pubmed:dateCreated | 1983-8-17 | lld:pubmed |
| pubmed-article:6409093 | pubmed:abstractText | We have developed a specific radioimmunoassay to quantify NADPH: cytochrome P-450 reductase. The assay is based on the use of 125I-labelled NADPH: cytochrome P-450 reductase as the radiolabelled antigen and can detect quantities of this protein in amounts as low as 30 pg. The results of the radioimmunoassay demonstrates that the 2.7-fold increase in enzyme activity in rat liver microsomal membranes after phenobarbital treatment is due to increased amounts of the protein. beta-Naphthoflavone treatment, however, did not alter the activity or the quantity of this enzyme in microsomes. The quantification of NADPH: cytochrome P-450 reductase in the microsomes isolated from control and phenobarbital- and beta-naphthoflavone-treated animals permits the calculation of the ratio of this protein to that of total cytochromes P-450. A molar ratio of 15:1 (cytochromes P-450/NADPH: cytochrome P-450 reductase) was calculated for control and phenobarbital-treated animals. This ratio increased to 21:1 after beta-naphthoflavone treatment. Thus the molar ratio of these proteins in liver microsomes can vary with exposure of the animals to particular xenobiotics. | lld:pubmed |
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| pubmed-article:6409093 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6409093 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6409093 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6409093 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6409093 | pubmed:month | May | lld:pubmed |
| pubmed-article:6409093 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:6409093 | pubmed:author | pubmed-author:RabinB RBR | lld:pubmed |
| pubmed-article:6409093 | pubmed:author | pubmed-author:PhillipsI RIR | lld:pubmed |
| pubmed-article:6409093 | pubmed:author | pubmed-author:ShephardE AEA | lld:pubmed |
| pubmed-article:6409093 | pubmed:author | pubmed-author:BayneyR MRM | lld:pubmed |
| pubmed-article:6409093 | pubmed:author | pubmed-author:PikeS FSF | lld:pubmed |
| pubmed-article:6409093 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6409093 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:6409093 | pubmed:volume | 211 | lld:pubmed |
| pubmed-article:6409093 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6409093 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6409093 | pubmed:pagination | 333-40 | lld:pubmed |
| pubmed-article:6409093 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6409093 | pubmed:meshHeading | pubmed-meshheading:6409093-... | lld:pubmed |
| pubmed-article:6409093 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6409093 | pubmed:articleTitle | Quantification of NADPH: cytochrome P-450 reductase in liver microsomes by a specific radioimmunoassay technique. | lld:pubmed |
| pubmed-article:6409093 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6409093 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:6409093 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6409093 | lld:pubmed |
