Linked Life Data

6407095

Source:http://linkedlifedata.com/resource/pubmed/id/6407095

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-7-15
pubmed:abstractText
A case of B-CLL in prolymphocytic transformation is described in which large numbers of peripheral blood mononuclear cells possess surface immunoglobulin and rosetted with AET-treated sheep erythrocytes (SIg+E+), but lacked specific T-cell antigens. The SIg (MDGK) was shown to be an intrinsic product of the cell, whose B-cell nature was confirmed by staining with BA1, a specific anti-B-cell monoclonal antibody. The E positivity resembled the rosetting of normal T cells in certain important respects but was weak, and aberrant in certain other respects. Although E rosetting was blocked with anti-chi and anti-D but not with anti-lambda, extensive blocking studies with a panel of monoclonal antibodies indicated that this was due to steric hindrance of weak E receptor rather than specific blocking of SIg possessing anti-E activity. The case is compared and contrasted with previous rare examples of SIg+E+ proliferations and briefly discussed in relation to the recent demonstration that certain non-T cells can express E receptor in vitro.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0036-553X
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
A B-cell proliferation with aberrant true E-rosette formation: a sequential study with a panel of monoclonal antibodies and other surface markers.
pubmed:publicationType
Journal Article, Case Reports