Linked Life Data

6406452

Source:http://linkedlifedata.com/resource/pubmed/id/6406452

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5 Pt 2
pubmed:dateCreated
1983-7-8
pubmed:abstractText
Tricyclic antidepressants may prolong cardiac conduction as a result of their direct cellular membrane depressant effects. These effects can be evaluated by careful quantitative assessment of the electrocardiogram (ECG). This study compared the ECG effects of bupropion and amitriptyline at therapeutically comparable doses. No significant changes were seen with bupropion in any of the ECG parameters measured (PR interval, QRS duration, QTc interval, and QRS height). Amitriptyline, however, caused a significant prolongation in PR interval (p less than .01) and QRS duration (p less than .05), as well as a decrease in QRS height (p less than .001). These results suggest that bupropion is less likely to cause cardiac conduction abnormalities in patients prone to such problems, or in those patients who overdose.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0160-6689
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
174-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Comparison of the effects of bupropion and amitriptyline on cardiac conduction in depressed patients.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Controlled Clinical Trial