| pubmed-article:6405280 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6405280 | lifeskim:mentions | umls-concept:C0080298 | lld:lifeskim |
| pubmed-article:6405280 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:6405280 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:6405280 | lifeskim:mentions | umls-concept:C0033681 | lld:lifeskim |
| pubmed-article:6405280 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:6405280 | lifeskim:mentions | umls-concept:C1150527 | lld:lifeskim |
| pubmed-article:6405280 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:6405280 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:6405280 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:6405280 | pubmed:issue | 5911 | lld:pubmed |
| pubmed-article:6405280 | pubmed:dateCreated | 1983-6-10 | lld:pubmed |
| pubmed-article:6405280 | pubmed:abstractText | Rous sarcoma virus (RSV) is an acutely oncogenic avian retrovirus which induces sarcomas in animals and transforms fibroblasts in cell culture. Genetic analysis indicates that the viral src gene (v-src) mediates neoplastic transformation. The product of v-src is a 60,000 molecular weight (MW) phosphoprotein (pp60v-src) possessing the enzymatic activity of a tyrosine-specific protein kinase. The viral src gene is derived from a cellular gene (c-src) which also encodes a 60,000 MW phosphoprotein (pp60c-src) with tyrosine-specific protein kinase activity. Both birds and mammals are known to possess c-src. Shilo and Weinberg have reported that the genome of the fruit fly, Drosophila melanogaster, contains nucleotide sequences that are homologous to v-src. We report here the molecular cloning and chromosomal mapping of three loci from the Drosophila genome that contain such sequences. We also show that Drosophila contain both phosphotyrosine and a tyrosine-specific protein kinase activity immunoprecipitated by antisera directed against pp60v-src. It should now be possible to identify the precise locus that encodes a src-specific protein kinase in Drosophila, and to explore the role of c-src in the growth and development of D. melanogaster. | lld:pubmed |
| pubmed-article:6405280 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6405280 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6405280 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6405280 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6405280 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:6405280 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:6405280 | pubmed:author | pubmed-author:BishopJ MJM | lld:pubmed |
| pubmed-article:6405280 | pubmed:author | pubmed-author:SimonM AMA | lld:pubmed |
| pubmed-article:6405280 | pubmed:author | pubmed-author:KornbergT BTB | lld:pubmed |
| pubmed-article:6405280 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6405280 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:6405280 | pubmed:volume | 302 | lld:pubmed |
| pubmed-article:6405280 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6405280 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6405280 | pubmed:pagination | 837-9 | lld:pubmed |
| pubmed-article:6405280 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:6405280 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6405280 | pubmed:articleTitle | Three loci related to the src oncogene and tyrosine-specific protein kinase activity in Drosophila. | lld:pubmed |
| pubmed-article:6405280 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6405280 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6405280 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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