Linked Life Data

6404616

Source:http://linkedlifedata.com/resource/pubmed/id/6404616

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-6-10
pubmed:abstractText
Abdominal aorta ligation in neonatal rats was used as a model to evaluate drug-metabolizing activities after trauma. Short-term ischemic trauma (24 h) was found to have a significant effect on hepatic microsomal cytochrome P-450 content, NADPH-cytochrome c reductase activity, and cytochrome P-450-dependent electron transport capacity. In pre-weanling animals, trauma caused a decrease in hepatic microsomal cytochrome P-450 content, but increased NADPH-cytochrome c reductase activity. The electron transport capacity of the cytochrome P-450 system is reduced in traumatized pre-weanling rats, suggesting that cytochrome P-450 may be the rate-limiting step for this enzyme system in animals of this age. After weaning, the electron transport capacity of this enzyme system is greater in traumatized animals than in control animals, indicating that a different rate-limiting factor dominates in these animals.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0379-8305
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
64-72
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Effect of short-term ischemic trauma on the hepatic cytochrome P-450 monooxygenase system in the neonatal rat.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't