Linked Life Data

6401428

Source:http://linkedlifedata.com/resource/pubmed/id/6401428

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-3-24
pubmed:abstractText
Seven different immunoglobulin G (IgG) preparations for intravenous use were tested for their capacity to inhibit serotonin-release from washed human platelets induced by IgG coupled with bis-diazobenzidine. Using a reference standard consisting of the top third fraction of an ultracentrifuged gammaglobulin preparation for intramuscular use, two chemically treated preparations were less potent inhibitors than the standard while two preparations, one pH 4 treated and another albumin protected, were better inhibitors. A pepsin treated preparation was devoid of inhibitory capacity, whereas Fc fragments derived from human IgG were extremely efficient. Evidence is discussed that the inhibitory capacity is inversely correlated to the content of oligo- and/or dimeric IgG molecules.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0007-1048
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
289-99
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Monomeric IgG preparations for intravenous use inhibit platelet stimulation by polymeric IgG.
pubmed:publicationType
Journal Article, In Vitro