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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1983-2-14
|
| pubmed:abstractText |
Administration of 5 g L-lysine orally to normal adults produced a significant increase in plasma carnitine levels within 6 h followed by a further rise by 48 h. Levels remained high up to 72 h. Similar changes in plasma carnitine were not observed if blood was sampled without lysine load or after administering a load of other amino acids such as tryptophan or threonine. Maximum excretion of carnitine per g creatinine was observed in 24 to 48 h collection after lysine load. Two subjects showed an early peak in 3-h and 6-h collections, respectively. Undernourished subjects failed to demonstrate similar change. After rehabilitation the undernourished subjects behaved as did the well-nourished subjects. These observations suggest that there may be a rapid in vivo conversion of orally administered lysine to carnitine in humans. Conversion of lysine to carnitine may be impaired in malnutrition.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0002-9165
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
37
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
93-8
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading | |
| pubmed:year |
1983
|
| pubmed:articleTitle |
Lysine-carnitine conversion in normal and undernourished adult men-suggestion of a nonpeptidyl pathway.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial
|