Linked Life Data

6400431

Source:http://linkedlifedata.com/resource/pubmed/id/6400431

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-8-11
pubmed:abstractText
To study the hitherto unknown long-term effects of ethanol on the contractile activity of wall cells of coronary microvessels (mv.), 21 experimental and 21 control animals were investigated, using a new histomorphometric method. The pair-fed rats of the experimental group were given a diet containing ethanol which replaced 36% of the total calories for 4 weeks. This resulted in an increase of wall thickness of mv. in all segments of the microvasculature and an augmentation of the number of ATP-hydrolyzing small-calibered mv. The increase of wall thickness of muscularized mv. was interpreted as a structural adaptation to a long-term predominance of vasotonic influences, which were apparently likewise responsible for the increase of ATP-hydrolysis in the smallest mv. The possible reasons for this predominance are discussed and the necessity to include myocardial metabolic factors in pathogenic considerations on ethanol-induced coronary affections is indicated. Such mv. reactions as observed may be considered as a potential contributive pathogenic factor in ethanol-induced cardiomyopathies and hypertension.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0740-9451
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
589-610
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Long-term effects of ethanol on coronary microvessels of rats.
pubmed:publicationType
Journal Article, Review