Linked Life Data

6400094

Source:http://linkedlifedata.com/resource/pubmed/id/6400094

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
59
pubmed:dateCreated
1986-2-10
pubmed:abstractText
The bacterial bioassay procedure provides a sensitive test for the presence of mutagenic activity in urine. Its sensitivity for detecting the presence of individual chemicals may not be as high as that of specific analytical methods, but it has the following advantages: (1) many substances and metabolites may be active in a single assay, making it possible to detect mutagenic activity from unanticipated sources; (2) biological activity is demonstrated, rather than simply the presence of substances; or (3) the assay may also reflect the 'integrated' effect of multiple substances, although this capability has not been well characterized and (4) the assay can be easily coupled with a chemical analysis. The chief disadvantages of the test system are lack of sensitivity for certain specific substances, as compared to chemical techniques, and possible interference from substances normally present in urine (such as amino acids). The urinary mutagenicity assay is most useful when exposure to carcinogens and mutagens is suspected but when the specific chemical is unknown, when chemical analytical techniques are not available or when exposure is to undefined complex mixtures.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-5038
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
247-58
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Bacterial urinary assay in monitoring exposure to mutagens and carcinogens.
pubmed:publicationType
Journal Article