Linked Life Data

6397690

Source:http://linkedlifedata.com/resource/pubmed/id/6397690

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1985-5-14
pubmed:abstractText
The mutagenic effects of monofunctional and bifunctional furocoumarins (psoralens) plus 365 nm radiation were analyzed in the yeast Saccharomyces cerevisiae. Per unit dose of 365-nm radiation, bifunctional compounds were more effective than were the monofunctional for the induction of reverse and forward mutations. The same was observed for the induction of 6-thioguanine-resistant mutants in V79 Chinese hamster cells when we compared the activity of 8-methoxypsoralen and 3-carbethoxypsoralen. An analysis of the kinetics of mutation induction indicated that DNA interstrand cross-links induced by bifunctional psoralens are more prone to error than are monoadducts induced by monofunctional psoralens. In yeast, 8-methoxypsoralen and 4,5'-dimethylangelicin were shown to photoinduce mitotic and nondisjunction. The implications of these findings for the use of psoralens in photochemotherapy and cosmetics are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0083-1921
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-36
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Mutagenic effects of psoralens in yeast and V79 Chinese hamster cells.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't