Linked Life Data

6394130

Source:http://linkedlifedata.com/resource/pubmed/id/6394130

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-3-21
pubmed:abstractText
Basic research in the neurosciences has led to a theory of opiate withdrawal involving endogenous opioid peptides and hyperactive norepinephrine neurons. This theory predicts the efficacy of clonidine, a nonopiate agent, in the management of opiate withdrawal. Clonidine, which offers numerous advantages over methadone as a means of opiate detoxification, may be appropriate for use by general practitioners. Clonidine-aided detoxification can be followed immediately by naltrexone maintenance, which facilitates rehabilitation. Cocaine users' reports and clinical and basic studies, when pieced together, provide an outline of the natural history of chronic cocaine abuse. How certain users become addicts is not clear, however. Additional neurochemical research and neurophysiological studies are needed for the development of nonaddictive methods of detoxification (à la clonidine) and prophylaxis (à la naltrexone). In the absence of such studies, cocaine treatment programs use the methods of Alcoholics Anonymous, contingency contracting, and inpatient therapies for addiction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0149-2918
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6-21
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
New insights and treatments: opiate withdrawal and cocaine addiction.
pubmed:publicationType
Journal Article, Review