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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1985-2-14
|
| pubmed:abstractText |
We have employed the plaque forming cell (PFC) response to sheep erythrocytes as well as lymphocyte proliferation to study the induction of immunotoxicity in AHH-inducible (Ah Locus positive, C57BL/6N; B6C3F1) and AHH non-inducible (Ah Locus negative, DBA2/N) mice following administration of polycyclic aromatic hydrocarbons. When two potent carcinogenic polycyclic hydrocarbons which induce AHH activity, 3-methylcholanthrene (MCA) or 1,2,5,6-dibenzanthracene [DB(a,h)A] were administered IP, immunotoxicity was observed in both AHH-inducible and AHH non-inducible animals. However, the AHH-inducible animals appeared to be more sensitive, and substantial suppression of a PFC response toxicity could be induced with doses as low as 14 mg/kg methylcholanthrene. While suppression of a mitogen response required a dose of 43-125 mg/kg. Administration of the weak carcinogen 1,2,3,4-dibenzanthracene [DB(a,c)A], IP, which similarly induces AHH activity in inducible animals, failed to induce immunotoxicity in either C57B1/6N or DBA/2N mice. In contrast to the results obtained following IP administration, when MCA was administered repeatedly (4X) via an intragastric (IG) route we observed striking immunosuppression of a PFC response in Ah locus negative (DBA/2) animals but minimal effects in Ah locus positive animals (C57B1/6). We finally observed that a single IP dose of MCA (125 mg/kg) to Ah locus positive animals substantially inhibited Natural Killer Cell activity but had more limited effects on the ability of an animal to reject a challenge by an immunogenic syngeneic fibrosarcoma.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A1,
http://linkedlifedata.com/resource/pubmed/chemical/Methylcholanthrene,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/Polycyclic Compounds
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0340-5761
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
56
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
18-24
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:6393912-Animals,
pubmed-meshheading:6393912-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:6393912-Cell Division,
pubmed-meshheading:6393912-Chromosome Mapping,
pubmed-meshheading:6393912-Cytochrome P-450 CYP1A1,
pubmed-meshheading:6393912-Enzyme Induction,
pubmed-meshheading:6393912-Fibrosarcoma,
pubmed-meshheading:6393912-Hemolytic Plaque Technique,
pubmed-meshheading:6393912-Immunity,
pubmed-meshheading:6393912-Immunity, Innate,
pubmed-meshheading:6393912-Killer Cells, Natural,
pubmed-meshheading:6393912-Lymphocytes,
pubmed-meshheading:6393912-Methylcholanthrene,
pubmed-meshheading:6393912-Mice,
pubmed-meshheading:6393912-Mice, Inbred C57BL,
pubmed-meshheading:6393912-Mice, Inbred DBA,
pubmed-meshheading:6393912-Oxidoreductases,
pubmed-meshheading:6393912-Polycyclic Compounds,
pubmed-meshheading:6393912-Sarcoma, Experimental,
pubmed-meshheading:6393912-Sheep
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Induction of immunotoxicity by polycyclic hydrocarbons: role of the Ah locus.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|