Linked Life Data

6393886

Source:http://linkedlifedata.com/resource/pubmed/id/6393886

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-2-14
pubmed:abstractText
Antiaggregatory potency and time courses of their respective efficacy were assessed for acetylsalicylic acid, prostaglandin (PGI2) and nafazatrom, a stimulator of PGI2-release from endothelial cells, and were compared in vivo. Endothelial cell damage was induced by excitation of intravascular fluoresceinisothio-cycanate-dextran. Time from onset of the noxious stimulus to aggregate appearance (TAA) was assessed and dose-dependently delayed by antithrombotic compounds. PGI2 was two orders of magnitude more effective than nafazatrom, acetylsalicylic acid was three orders of magnitude less effective than nafazatrom. Whereas the antiaggregatory potency of PGI2 decreased after 3.1 min to 50%, the antithrombotic efficacy of both, ASA and nafazatrom, further increased after a single bolus injection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0301-4533
pubmed:author
pubmed:issnType
Print
pubmed:volume
272
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
150-8
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Antiaggregatory efficacy and its time-course after application of acetylsalicylic acid, prostacyclin and nafazatrom in vivo.
pubmed:publicationType
Journal Article