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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1985-1-25
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pubmed:abstractText |
Monensin, a specific sodium ionophore, has been shown to reduce glucose-induced proinsulin biosynthesis by 30% and to completely inhibit the intracellular conversion of proinsulin to insulin. Autoradiography of monensin-treated cells demonstrated the presence of large quantities of newly synthesized proteins in amorphous vesicles close to the Golgi complex of B cells. The results suggest profound effects of monensin on biosynthesis and intracellular processing of proinsulin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0144-8463
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
737-42
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6391571-Animals,
pubmed-meshheading:6391571-Autoradiography,
pubmed-meshheading:6391571-Cells, Cultured,
pubmed-meshheading:6391571-Furans,
pubmed-meshheading:6391571-Iodine Radioisotopes,
pubmed-meshheading:6391571-Islets of Langerhans,
pubmed-meshheading:6391571-Kinetics,
pubmed-meshheading:6391571-Microscopy, Electron,
pubmed-meshheading:6391571-Monensin,
pubmed-meshheading:6391571-Proinsulin,
pubmed-meshheading:6391571-Protein Processing, Post-Translational,
pubmed-meshheading:6391571-Rats,
pubmed-meshheading:6391571-Rats, Inbred Strains,
pubmed-meshheading:6391571-Tritium
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pubmed:year |
1984
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pubmed:articleTitle |
Effects of monensin on biosynthesis and intracellular processing of proinsulin.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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