Linked Life Data

6391209

Source:http://linkedlifedata.com/resource/pubmed/id/6391209

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6 Pt 2
pubmed:dateCreated
1985-1-24
pubmed:abstractText
The relative roles of cardiopulmonary, sinoaortic, and renal baroreceptors in the regulation of plasma renin activity (PRA) were evaluated in dogs with chronically implanted cuffs around the ascending aorta proximal to the brachiocephalic artery, the abdominal aorta just proximal to both renal arteries, or both. Inflation of either cuff was adjusted to cause a reduction of distal arterial pressure and hence renal perfusion pressure (RPP) of 0, 5, 10, 20, or 30% of control for 1 h. Reduction of RPP by inflation of the suprarenal cuff (n = 4) led to a significant (P less than 0.05) increase in PRA throughout the dose range examined. However, constriction of the ascending aorta (n = 7) to cause identical reductions in RPP failed to increase PRA. The apparent paradox in these results may be explained by differential effects of the two maneuvers on left atrial pressure. Left atrial pressure increased dose dependently during inflation of the ascending aortic cuff but did not change during inflation of the suprarenal cuff. To determine if elevated right atrial pressure (RAP) would inhibit renin release after systemic hypotension, another group of dogs (n = 4) was prepared with cuffs around the pulmonary artery. Inflation of the pulmonary cuff to cause similar systemic hypotension led to significant (P less than 0.05) increases in PRA and RAP. Therefore we conclude that powerful inhibitory signals, arising from the left heart, can inhibit renin release in response to systemic hypotension.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
247
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R953-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Elevated cardiac pressure inhibits renin release after arterial hypotension in conscious dogs.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.