| pubmed-article:6390619 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6390619 | lifeskim:mentions | umls-concept:C0003259 | lld:lifeskim |
| pubmed-article:6390619 | lifeskim:mentions | umls-concept:C0544886 | lld:lifeskim |
| pubmed-article:6390619 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6390619 | pubmed:dateCreated | 1985-1-18 | lld:pubmed |
| pubmed-article:6390619 | pubmed:abstractText | Nucleotide insertions or deletions determine novel amino acid sequences at the VH-D and D-JH junction sites. Since these cannot be predicted by known coding genes, they are regarded as a form of somatic mutagenesis. A second type of somatic mutation in Ig structural genes are the stochastic base substitutions that have now been found in both V region coding sequences and noncoding flanking sequences. It has been proposed that this form of mutagenesis may be related to the gene rearrangement process as well. A third type of mutagenesis has been associated with Ig CH switching. In this case, a higher frequency of substitutions has been observed in VH regions associated with C gamma and C alpha. A mechanism for the origin of this phenomenon is not known. An unexpectedly high rate of mutagenesis affecting Ig V genes has been observed to occur spontaneously in vitro. | lld:pubmed |
| pubmed-article:6390619 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6390619 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6390619 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6390619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6390619 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6390619 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6390619 | pubmed:issn | 0253-438X | lld:pubmed |
| pubmed-article:6390619 | pubmed:author | pubmed-author:PotterMM | lld:pubmed |
| pubmed-article:6390619 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6390619 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:6390619 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6390619 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6390619 | pubmed:pagination | 139-48 | lld:pubmed |
| pubmed-article:6390619 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
| pubmed-article:6390619 | pubmed:meshHeading | pubmed-meshheading:6390619-... | lld:pubmed |
| pubmed-article:6390619 | pubmed:meshHeading | pubmed-meshheading:6390619-... | lld:pubmed |
| pubmed-article:6390619 | pubmed:meshHeading | pubmed-meshheading:6390619-... | lld:pubmed |
| pubmed-article:6390619 | pubmed:meshHeading | pubmed-meshheading:6390619-... | lld:pubmed |
| pubmed-article:6390619 | pubmed:meshHeading | pubmed-meshheading:6390619-... | lld:pubmed |
| pubmed-article:6390619 | pubmed:meshHeading | pubmed-meshheading:6390619-... | lld:pubmed |
| pubmed-article:6390619 | pubmed:meshHeading | pubmed-meshheading:6390619-... | lld:pubmed |
| pubmed-article:6390619 | pubmed:meshHeading | pubmed-meshheading:6390619-... | lld:pubmed |
| pubmed-article:6390619 | pubmed:meshHeading | pubmed-meshheading:6390619-... | lld:pubmed |
| pubmed-article:6390619 | pubmed:meshHeading | pubmed-meshheading:6390619-... | lld:pubmed |
| pubmed-article:6390619 | pubmed:meshHeading | pubmed-meshheading:6390619-... | lld:pubmed |
| pubmed-article:6390619 | pubmed:meshHeading | pubmed-meshheading:6390619-... | lld:pubmed |
| pubmed-article:6390619 | pubmed:meshHeading | pubmed-meshheading:6390619-... | lld:pubmed |
| pubmed-article:6390619 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6390619 | pubmed:articleTitle | Somatic mutation and antibody diversity. | lld:pubmed |
| pubmed-article:6390619 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6390619 | pubmed:publicationType | Review | lld:pubmed |
