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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1985-1-18
|
pubmed:abstractText |
Nucleotide insertions or deletions determine novel amino acid sequences at the VH-D and D-JH junction sites. Since these cannot be predicted by known coding genes, they are regarded as a form of somatic mutagenesis. A second type of somatic mutation in Ig structural genes are the stochastic base substitutions that have now been found in both V region coding sequences and noncoding flanking sequences. It has been proposed that this form of mutagenesis may be related to the gene rearrangement process as well. A third type of mutagenesis has been associated with Ig CH switching. In this case, a higher frequency of substitutions has been observed in VH regions associated with C gamma and C alpha. A mechanism for the origin of this phenomenon is not known. An unexpectedly high rate of mutagenesis affecting Ig V genes has been observed to occur spontaneously in vitro.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0253-438X
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
3
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
139-48
|
pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:6390619-Amino Acid Sequence,
pubmed-meshheading:6390619-Animals,
pubmed-meshheading:6390619-Antibody Diversity,
pubmed-meshheading:6390619-B-Lymphocytes,
pubmed-meshheading:6390619-Cell Line,
pubmed-meshheading:6390619-Genes,
pubmed-meshheading:6390619-Immunoglobulin Variable Region,
pubmed-meshheading:6390619-Immunoglobulins,
pubmed-meshheading:6390619-Mice,
pubmed-meshheading:6390619-Models, Genetic,
pubmed-meshheading:6390619-Mutation,
pubmed-meshheading:6390619-Recombination, Genetic,
pubmed-meshheading:6390619-Templates, Genetic
|
pubmed:year |
1984
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pubmed:articleTitle |
Somatic mutation and antibody diversity.
|
pubmed:publicationType |
Journal Article,
Review
|