Linked Life Data

6388755

Source:http://linkedlifedata.com/resource/pubmed/id/6388755

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1985-1-14
pubmed:abstractText
This paper describes some mathematical models for studying properties of lipid bilayer membranes. It is shown that there is evidence from fluorescent probe and electron spin resonance studies that some integral proteins are "randomly" distributed in the plane of a lipid bilayer for T greater than Tc, so that protein-protein "contacts" can occur. This implies that there is no permanent annulus of lipids around these proteins, so that there is no unique stoichiometric ratio of "boundary lipids" to protein. Computer simulation techniques are reviewed and comments are made about some recently introduced methods. Dynamical models of lipid--integral protein bilayers are outlined and it is shown that much differential scanning calorimetry, freeze-fracture, X-ray, and 2H nuclear magnetic resonance data can be understood. It is predicted that specific heat curves should show a rise at a temperature, TK less than Tc, at which a protein-rich phase starts to "melt"; that dipalmitoyl phosphatidylcholine (DPPC) hydrocarbon chains in such a protein-rich phase should exhibit some static disorder down to approximately -10 degrees C, around which they should freeze noncooperatively; and that the crossing of phase boundaries, as protein concentration expressed as mole fraction X changes just below Tc, should be reflected in a complicated dependence of protein lateral motion upon X. Models to study the liquid condensed-liquid expanded (LC-LE) transition of phosphatidylcholine (PC) monolayers at the air-water interface are described. The rounding in the LC phase of pressure-area isotherms are understood as the melting of microscopic gel-phase "domains" into macroscopic regions of fluid-phase lipids. There is some experimental support for this. Finally, to model the difference between a monolayer and the corresponding bilayer, an interaction is introduced between the two halves of a bilayer. It is shown to be very weak in the case of PC bilayers and it is outlined in the paper how monolayer and bilayer thermodynamics can be related. It was found that the internal lateral pressure of a DPPC bilayer is approximately 30 dyn/cm (1 dyn = 10 microN).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0714-7511
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
760-77
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Theoretical studies of phospholipid bilayers and monolayers. Perturbing probes, monolayer phase transitions, and computer simulations of lipid-protein bilayers.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't