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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
17
|
| pubmed:dateCreated |
1984-11-9
|
| pubmed:abstractText |
Neonatal hyaline-membrane disease is complicated by pulmonary edema, yet left atrial pressures are normal. Alveolar-capillary-membrane permeability may therefore be increased. To assess pulmonary epithelial permeability, we measured the pulmonary clearance and half-life of aerosolized 99mTc-diethylenetriamine pentacetate (99mTc-DTPA) on 31 occasions in 15 intubated premature infants with hyaline-membrane disease. Three infants with respiratory failure due to other diseases were studied on four occasions. All studies of infants with hyaline-membrane disease that were performed in the first 72 hours of life demonstrated a biphasic clearance curve with a rapid-phase half-life of 1.6 +/- 0.6 minutes (mean +/- S.D.). As these infants recovered, the curve became monophasic with a half-life of 56.0 +/- 32.1 minutes. Two infants remained dependent on oxygen and ventilator support and had persistent biphasic curves with a rapid-phase half-life of 1.5 +/- 0.7 minutes. All infants without hyaline-membrane disease had monophasic curves with a half-life of 65.4 +/- 33.6 minutes. Using a similar technique, we observed that newborn lambs and piglets have a monophasic pulmonary clearance of 99mTc-DTPA (114 +/- 59 minutes in lambs and 52.5 +/- 16.3 minutes in piglets). We conclude that the lungs of neonates with hyaline-membrane disease are abnormally permeable to small solutes and that this abnormality persists in infants with subsequent chronic lung disease.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0028-4793
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
25
|
| pubmed:volume |
311
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1075-80
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6384782-Aerosols,
pubmed-meshheading:6384782-Animals,
pubmed-meshheading:6384782-Capillary Permeability,
pubmed-meshheading:6384782-Epithelium,
pubmed-meshheading:6384782-Female,
pubmed-meshheading:6384782-Half-Life,
pubmed-meshheading:6384782-Humans,
pubmed-meshheading:6384782-Hyaline Membrane Disease,
pubmed-meshheading:6384782-Infant, Newborn,
pubmed-meshheading:6384782-Lung,
pubmed-meshheading:6384782-Male,
pubmed-meshheading:6384782-Pentetic Acid,
pubmed-meshheading:6384782-Pulmonary Alveoli,
pubmed-meshheading:6384782-Pulmonary Edema,
pubmed-meshheading:6384782-Sheep,
pubmed-meshheading:6384782-Swine,
pubmed-meshheading:6384782-Technetium,
pubmed-meshheading:6384782-Technetium Tc 99m Pentetate
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Pulmonary epithelial permeability in hyaline-membrane disease.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|