Linked Life Data

6384659

Source:http://linkedlifedata.com/resource/pubmed/id/6384659

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1984-11-13
pubmed:abstractText
The renin content of human pituitaries obtained at autopsy of eight patients (four males and four females) within 3 hours after death from various diseases was determined. The pituitaries contained a significant amount of renin (5.5 +/- 1.6 mg of angiotensin I/mg of protein/hour). Although much less (1/1000) than that in human kidneys (4.5 micrograms of angiotensin I/mg of protein/hour), this content was about 10 times higher than that in normal plasma (0.5 ng of angiotensin I/mg of protein/hour). More than 50% of the renin activity was inhibited by antihuman renin antibody. These results are the first detection of a significant amount of renin in the human pituitary. No difference in pituitary renin content between males and females was detected; the pituitaries from the two youngest patients showed the highest levels. Immunohistochemical staining showed no positive cells in the intermediate and posterior lobes and many positive cells in the anterior lobe. Serial sections were examined, and renin-containing cells were immunohistochemically identified as polactin-producing cells without distinction as to the sex of the donor. This demonstration of the intracellular presence of immunoreactive renin lends strong support to the idea that renin is not a contaminant of pituitary preparations due to entrapped plasma, but is endogenous to the human pituitary.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0023-6837
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
425-8
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Biochemical and immunohistochemical localization of renin in human pituitary.
pubmed:publicationType
Journal Article