Linked Life Data

6381599

Source:http://linkedlifedata.com/resource/pubmed/id/6381599

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-10-2
pubmed:abstractText
The relation between avidity and specificity of monoclonal antibodies to Chlamydia trachomatis elementary body antigens was studied by enzyme immunoassay. Avidity was estimated by performing the assay in 6 sample dilutions and using a curve-fitting procedure to extrapolate antibody binding in the presence of large antibody excess. Specificity was judged by the difference between end-point titers against homologous and heterologous antigens. By this method antibodies are divided into 2 groups, high specificity (Hs) and low specificity (Ls). Usually, antibodies from ascitic fluids belonged to the Ls group. However, the Ls group also included a few antibodies in supernatants. There was an inverse relationship between avidity and specificity in the Ls group. Immunoglobulin M (IgM) and IgG antibodies of the Hs group had different relative avidities. Avid IgM antibodies from ascitic fluid are not necessarily highly specific.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-1759
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
341-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Relation between avidity and specificity of monoclonal anti-chlamydial antibodies in culture supernatants and ascitic fluids determined by enzyme immunoassay.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't