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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1984-10-19
|
| pubmed:abstractText |
The splenic component of reticulophagocytic function (RPF) was examined in 29 insulin-treated diabetic subjects (13 type I and 16 type II) by measurement of clearance of altered, radiolabeled, autologous erythrocytes. Double-isotope studies were performed with cells altered by: (1) preincubation with N-ethylmaleimide (NEM) and (2) coating with IgG antibody to the Rhesus (Rh) D antigen, labeled with 99mTc and 51Cr, respectively. HLA typing for the A, B, and DR loci was performed in those patients showing a defect in the clearance of IgG-coated cells. Values for half-life (t1/2) were correlated with the incidence of diabetic complications, levels of HbA1, and circulating immune complexes (CIC). Two patterns of abnormal clearance were observed: first, an isolated defect of IgG-coated cell clearance in 7 patients (3 had the HLA B8/DR3 haplotype) and second, abnormal removal of both types of cell in a further 7 patients (3 had B8/DR3). There was no correlation between half-lives as measured by the two methods, although exclusion of the patients with a defect of IgG-coated cell clearance alone yielded a highly significant correlation for the remaining 15 Rh-positive patients (P less than 0.01). Abnormalities of IgG-coated cell clearance were more frequent in patients with HbA1 greater than 9% (P less than 0.02), while t1/2 of NEM-altered cells was significantly greater in patients with CIC (P less than 0.05). There was no correlation between t1/2 and the incidence of peripheral complications.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigen-Antibody Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Chromium Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Complement System Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HLA Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Technetium
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0012-1797
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
33
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
813-8
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:6381177-Adolescent,
pubmed-meshheading:6381177-Adult,
pubmed-meshheading:6381177-Aged,
pubmed-meshheading:6381177-Animals,
pubmed-meshheading:6381177-Antigen-Antibody Complex,
pubmed-meshheading:6381177-Chromium Radioisotopes,
pubmed-meshheading:6381177-Complement System Proteins,
pubmed-meshheading:6381177-Diabetes Mellitus,
pubmed-meshheading:6381177-Diabetes Mellitus, Type 1,
pubmed-meshheading:6381177-Diabetes Mellitus, Type 2,
pubmed-meshheading:6381177-Diabetic Nephropathies,
pubmed-meshheading:6381177-Diabetic Retinopathy,
pubmed-meshheading:6381177-Erythrocytes,
pubmed-meshheading:6381177-Female,
pubmed-meshheading:6381177-HLA Antigens,
pubmed-meshheading:6381177-Half-Life,
pubmed-meshheading:6381177-Humans,
pubmed-meshheading:6381177-Immunoglobulin G,
pubmed-meshheading:6381177-Insulin,
pubmed-meshheading:6381177-Macrophages,
pubmed-meshheading:6381177-Male,
pubmed-meshheading:6381177-Middle Aged,
pubmed-meshheading:6381177-Rabbits,
pubmed-meshheading:6381177-Reticulocytes,
pubmed-meshheading:6381177-Spleen,
pubmed-meshheading:6381177-Technetium
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Factors influencing reticulophagocytic function in insulin-treated diabetes.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|