Linked Life Data

6378703

Source:http://linkedlifedata.com/resource/pubmed/id/6378703

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1984-9-6
pubmed:abstractText
T-lymphocyte lines specific for islet cell antigens were isolated from the spleen and pancreas of newly diabetic BB rats or from the related strain BBUF. These cell lines were grown in continuous culture with interleukin-2 (IL-2) containing medium for greater than 60 days. Such T-lymphocytes responded by proliferation and IL-2 secretion in the combined presence of islet cell antigens and major histocompatibility (MHC)-matched antigen-presenting cells. By fluorescence-activated cell sorter (FACS) analysis the cells were W3/13+, W3/25+, and OX8-. Thus, both functionally and by cell-surface-marker analysis they appear to be of the T-helper phenotype. The long-term growth and study of anti-islet T-lymphocyte lines will permit a detailed analysis of the role of T-lymphocytes in the pathogenesis of IDDM.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0012-1797
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
801-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Isolation of T-lymphocyte lines with specificity for islet cell antigens from spontaneously diabetic (insulin-dependent) rats.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't