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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1984-8-24
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pubmed:abstractText |
The three-dimensional structure of the fungal serine protease proteinase K has been determined at 3.3 A resolution by single crystal X-ray diffraction analysis. The enzyme crystallizes in the tetragonal space group P4(3)2(1)2 with cell constants a = b = 68.3 A, c = 108.5 A. The asymmetric unit consists of one monomer of 27 000 daltons mol. wt., approximately 50% higher than the so far assumed value of 18 500 daltons. The main chain fold of proteinase K shows a high degree of tertiary homology with the corresponding bacterial subtilisin BPN'. Proteinase K is the second enzyme in this family of serine proteases to be studied by X-ray diffraction, thus confirming the existence of two unrelated families of serine proteases in pro-and eukaryotes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6378621-1236959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6378621-386412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6378621-4373242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6378621-4818352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6378621-5159785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6378621-5285752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6378621-5700707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6378621-5763076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6378621-6774102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6378621-6866082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6378621-875032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6378621-943367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6378621-96440
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1311-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1984
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pubmed:articleTitle |
Three-dimensional structure of fungal proteinase K reveals similarity to bacterial subtilisin.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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