Linked Life Data

6375552

Source:http://linkedlifedata.com/resource/pubmed/id/6375552

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1984-7-9
pubmed:abstractText
The purpose of this study was to determine the pharmacokinetics and bacteriological effect of mezlocillin in experimental meningitis caused by Listeria monocytogenes and two Escherichia coli strains. The half-life of mezlocillin in cerebrospinal fluid (CSF) was approximately twice that in serum of experimentally infected animals, and the penetration of drug into CSF was 5 to 15% after a single dose and 5 to 20% after continuous-infusion experiments. The bactericidal titer in CSF for both susceptible E. coli and L. monocytogenes was 1:8, whereas for the resistant E. coli strain, titers were less than 1:2 after single doses of 50 or 100 mg of mezlocillin per kg and 1:4 with continuous infusion. After single-dose and continuous-infusion experiments, the bacteriological effect of mezlocillin in experimental L. monocytogenes infections was similar to that of ampicillin. Mezlocillin reduced the colony counts of of susceptible E. coli in CSF by 90% or more after a single dose or continuous infusion but had no appreciable effect on resistant E. coli after a single dose of 50 mg/kg. In contrast, a single dose of 100 mg of mezlocillin per kg eradicated the resistant strain from CSF, despite a bactericidal titer in CSF of less than 1:2. This unexpected finding prompted us to evaluate the effect of serum on the in vitro susceptibilities of selected coliforms to mezlocillin. The activity of mezlocillin against one susceptible and four resistant strains of gram-negative, enteric bacilli was enhanced manyfold by the addition of fresh rabbit serum; this effect was abolished by heating the serum at 56 degrees C for 30 min. This interaction of mezlocillin and serum against coliform bacteria should be examined in a larger number of experimentally infected animals and in specimens obtained from mezlocillin-treated infants.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6375552-115932, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375552-352265, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375552-4157341, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375552-5328466, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375552-6210656, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375552-6210683, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375552-6217786, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375552-627734, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375552-6280599, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375552-6322679, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375552-6340600, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375552-6448576, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375552-677860, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375552-7005676, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375552-879747
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
427-32
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Pharmacokinetics and bacteriological efficacy of mezlocillin in experimental Escherichia coli and Listeria monocytogenes meningitis.
pubmed:publicationType
Journal Article