Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-7-19
pubmed:abstractText
Uroporphyrinogen decarboxylase activity was measured in hemoglobin-free lysates from two patients with hepatoerythropoietic porphyria (HEP) and from 12 unrelated patients with familial porphyria cutanea tarda (PCT). In HEP patients, enzyme activities were 5% of normal, and familial studies clearly confirmed that patients with HEP are cases of homozygous PCT. Immunoreactive uroporphyrinogen decarboxylase was measured by developing a direct and noncompetitive enzyme immunoassay (EIA). For the 12 familial PCT patients, we found an immunoreactive protein decreased (51%) to the same extent as the catalytic activity (48%) [cross-reactive immunological material ( CRIM ) negative]. The children from the HEP family were also CRIM negative, contrasting with another HEP family previously described as CRIM positive; our data support the hypothesis of a heterogeneity in familial uroporphyrinogen decarboxylase deficiency.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-13295297, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-4103787, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-4853698, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-5150003, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-5473577, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-5778714, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-6112327, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-6134095, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-661926, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-6822570, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-6886003, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-69063, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-703786, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-7059676, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-7062951, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-7114869, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-7251856, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-730158, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-7350915, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-7369748, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-7428280, http://linkedlifedata.com/resource/pubmed/commentcorrection/6375356-993332
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0002-9297
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
613-22
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Enzymatic and immunological studies of uroporphyrinogen decarboxylase in familial porphyria cutanea tarda and hepatoerythropoietic porphyria.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't