Linked Life Data

637331

Source:http://linkedlifedata.com/resource/pubmed/id/637331

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1978-5-24
pubmed:abstractText
Sensitivities to epinephrine in fasted and non-fasted rats anesthetized with halothane or pentobarbital were determined. The arrhythmic threshold for epinephrine, i.e., the dose which upon injection produced four or more premature ventricular contractions, was significantly lower for 12-hour (5.5 +/- 3.2 microgram/kg), 24-hour (2.2 +/- 1.3 microgram/kg) and 48-hour (2.25 +/- 0.6 microgram/kg) fasted rats than for non-fasted rats (10.9 +/- 3.4 microgram/kg) at the same dose of halothane (2.0 per cent). Fasting had no effect on the arrhythmic threshold for epinephrine in rats anesthetized with pentobarbital (35 mg/kg). Infusion of a 10 per cent fatty acid emulsion caused a significant lowering of the arrhythmic threshold for epinephrine of fed rats, while infusion of acetoacetic acid had no effect on the arrhythmic threshold. It is concluded that the combination of fasting and halothane anesthesia renders the heart more sensitive to epinephrine than halothane anesthesia alone.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0003-3022
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
245-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Responses to fasting and lipid infusion of epinephrine-induced arrhythmias during halothane anesthesia.
pubmed:publicationType
Journal Article