Linked Life Data

6371253

Source:http://linkedlifedata.com/resource/pubmed/id/6371253

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-6-13
pubmed:abstractText
The use of aequorin as an intracellular calcium indicator in ventricular muscle is described. If the increase of intracellular calcium concentration associated with each contraction (the calcium transient) is measured during inotropic interventions, it is possible to distinguish two classes of inotropic intervention. One class leads to changes in the calcium transient which parallel the changes in tension. The second class leads to changes in the calcium transient and tension which are different in magnitude or direction. In this latter class, changes in the sensitivity of the contractile proteins to calcium are occurring and represent an important part of the inotropic mechanism. When oxidative phosphorylation is inhibited in an isolated mammalian papillary muscle, tension declines but the amplitude of the calcium transients is unaffected. Intracellular acidosis caused by lactate production associated with the increased rate of glycolysis is the probable mechanism of this decline in tension. When both oxidative phosphorylation and glycolysis are inhibited, both the calcium transient and the developed tension decline rapidly to zero. This profound contractile failure may be a consequence of a decline in the free energy of hydrolysis of ATP so that the sarcoplasmic reticulum can no longer accumulate calcium. Hypoxic contractures occur in the absence of significant increases in resting [Ca2+]i and are probably due to rigor produced by the low [ATP].
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-2828
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
117-28
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Measurements of intracellular calcium concentration in heart muscle: the effects of inotropic interventions and hypoxia.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't