Linked Life Data

6370573

Source:http://linkedlifedata.com/resource/pubmed/id/6370573

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-6-18
pubmed:abstractText
In vitro inactivation of aminoglycosides (tobramycin, gentamicin, and amikacin) by beta-lactams (cefazolin, cefotaxime, moxalactam, carbenicillin, piperacillin, mezlocillin, and azlocillin) was measured using the enzyme-mediated immunoassay (EMIT), fluorescence polarization immunoassay ( TDX ), radioimmunoassay (RIA), and bioassay. No significant inactivation of aminoglycosides was produced by high levels of the three cephalosporins as measured by EMIT, RIA, or bioassay. Inactivation of tobramycin and gentamicin by mezlocillin and azlocillin was comparable to that seen with piperacillin but less than that with carbenicillin. In general, the bioassay detected the greatest degree of aminoglycoside inactivation and the EMIT assay detected the least for all drug combinations. The TDX and RIA techniques were equivalent in their ability to detect aminoglycoside inactivation by beta-lactam antibiotics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0732-8893
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
93-100
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Comparative study of the ability of four aminoglycoside assay techniques to detect the inactivation of aminoglycosides by beta-lactam antibiotics.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro