Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1984-5-14
|
| pubmed:abstractText |
A rabbit antiserum was produced against a high-molecular-weight fraction (360,000) of murine Lewis lung carcinoma (LLC)-conditioned media. This fraction contained a factor that increased the rate of random migration (chemokinesis) of activated macrophages (M phi) in male C57BL/6J mice. The specificity of the antiserum was demonstrated by the ability of the antiserum to absorb the chemokinetic activity from tumor-conditioned media. Immunofluorescence studies demonstrated cell surface localization of antigenetically similar material on the LLC, Ehrlich ascites cells, MCA9/14 and MCA64/8 mouse fibrosarcomas, and MBT-2 mouse bladder carcinoma. The antiserum further indicated the presence of the chemokinetic factor (CKF) on the surface of peritoneal M phi previously exposed to tumor media. The CKF was observed on approximately 90% of the Corynebacterium parvum-activated M phi and of the M phi activated by maleic anhydride-divinyl ether copolymer (fraction 2), on 10% of the oyster glycogen-elicited M phi, and on 0% of the unstimulated M phi. these data support the concept that the CKF is a common surface marker of neoplastic cells and that it is bound by activated tumoricidal M phi.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0027-8874
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
72
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
871-84
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6368941-Animals,
pubmed-meshheading:6368941-Carcinoma, Ehrlich Tumor,
pubmed-meshheading:6368941-Cell Line,
pubmed-meshheading:6368941-Cell Membrane,
pubmed-meshheading:6368941-Cell Movement,
pubmed-meshheading:6368941-Chemotactic Factors,
pubmed-meshheading:6368941-Culture Media,
pubmed-meshheading:6368941-Fibrosarcoma,
pubmed-meshheading:6368941-Fluorescent Antibody Technique,
pubmed-meshheading:6368941-Histocytochemistry,
pubmed-meshheading:6368941-Immune Sera,
pubmed-meshheading:6368941-Lung Neoplasms,
pubmed-meshheading:6368941-Macrophage Activation,
pubmed-meshheading:6368941-Macrophages,
pubmed-meshheading:6368941-Male,
pubmed-meshheading:6368941-Mice,
pubmed-meshheading:6368941-Mice, Inbred C57BL,
pubmed-meshheading:6368941-Neoplasms,
pubmed-meshheading:6368941-Urinary Bladder Neoplasms
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Localization of a macrophage chemokinetic factor on neoplastic cells.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|