| pubmed-article:6366573 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6366573 | lifeskim:mentions | umls-concept:C0026922 | lld:lifeskim |
| pubmed-article:6366573 | lifeskim:mentions | umls-concept:C0023343 | lld:lifeskim |
| pubmed-article:6366573 | lifeskim:mentions | umls-concept:C0017950 | lld:lifeskim |
| pubmed-article:6366573 | lifeskim:mentions | umls-concept:C1518065 | lld:lifeskim |
| pubmed-article:6366573 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:6366573 | lifeskim:mentions | umls-concept:C1710548 | lld:lifeskim |
| pubmed-article:6366573 | pubmed:issue | 5955 | lld:pubmed |
| pubmed-article:6366573 | pubmed:dateCreated | 1984-4-13 | lld:pubmed |
| pubmed-article:6366573 | pubmed:abstractText | Leprosy remains a significant medical and social problem in many developing countries. The varied forms of the disease form a spectrum. At one pole, tuberculoid leprosy, patients develop high levels of cell-mediated immunity which results in the killing and clearing of bacilli in the tissues. At the lepromatous pole, patients exhibit a selective immunological unresponsiveness to antigens of Mycobacterium leprae so that the organisms inexorably multiply in the skin. We have suggested that in lepromatous leprosy one or a small number of unique antigenic determinants present on M. leprae might induce specific suppressor cells that inhibit the reactivity of helper T-cell clones capable of recognizing other specific or cross reactive determinants. Although unique epitopes have been identified by monoclonal antibodies on a small number of M. leprae proteins, the only unique species of antigen present in M. leprae, and not on any other species of mycobacteria so far examined, is a phenolic glycolipid (gly-I). We show here that this unique antigen of M. leprae is capable of inducing suppression of mitogenic responses of lepromatous patients' lymphocytes in vitro and provide evidence that the suppressor T cells recognize the specific terminal trisaccharide moiety. | lld:pubmed |
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| pubmed-article:6366573 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6366573 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6366573 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6366573 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6366573 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:6366573 | pubmed:author | pubmed-author:ConvitJJ | lld:pubmed |
| pubmed-article:6366573 | pubmed:author | pubmed-author:BloomB RBR | lld:pubmed |
| pubmed-article:6366573 | pubmed:author | pubmed-author:MehraVV | lld:pubmed |
| pubmed-article:6366573 | pubmed:author | pubmed-author:BrennanP JPJ | lld:pubmed |
| pubmed-article:6366573 | pubmed:author | pubmed-author:RadoSS | lld:pubmed |
| pubmed-article:6366573 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6366573 | pubmed:volume | 308 | lld:pubmed |
| pubmed-article:6366573 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6366573 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6366573 | pubmed:pagination | 194-6 | lld:pubmed |
| pubmed-article:6366573 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:6366573 | pubmed:articleTitle | Lymphocyte suppression in leprosy induced by unique M. leprae glycolipid. | lld:pubmed |
| pubmed-article:6366573 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6366573 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6366573 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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