Linked Life Data

6365807

Source:http://linkedlifedata.com/resource/pubmed/id/6365807

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1984-4-16
pubmed:abstractText
The gastrointestinal absorption of sfericase was determined using rabbits. Serum sfericase level was measured by ATNE of a specific substrate. The addition of anti-sfericase antibody resulted in pronounced decrease in ATNE-hydrolyzing activity of sfericase, so that the hydrolyzing activity in serum was confirmed to be due to sfericase. Although a great individual difference was observed, the absorption rates of sfericase following intraduodenal administration of sfericase powder at dosages of 10 mg/kg (n = 4), 20 mg/kg (n = 4), and 100 mg/kg (n = 1) dissolved in physiologic saline were 0.380%, 0.267%, and 0.706%, respectively. When a single dose of sfericase enteric granules (sfericase content was 36.8%) was given orally at dosages of 250 mg, 500 mg, and 1 g (two animals were used for each dose level), a measurable amount of sfericase appeared in the serum 0.5-1 h after administration. The same enteric granules were given at a dosage of 1 g/animal/day for 10 days or at 250 mg/animal/day for 20 days continuously to determine changes in the gastrointestinal absorption rate. Continued administration of sfericase had no influence on its gastrointestinal absorption.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0174-4879
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
617-23
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Gastrointestinal absorption of sfericase.
pubmed:publicationType
Journal Article, Comparative Study