Linked Life Data

6361125

Source:http://linkedlifedata.com/resource/pubmed/id/6361125

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-2-14
pubmed:abstractText
Immunoglobulins (Ig) were purified from serum or ascitic fluids of Saimiri monkeys infected with Plasmodium falciparum and with differing levels of functional immunity. Their protective activity was assessed in studies of passive transfer of immunity in vivo, and their neutralizing activity was measured in studies of parasite inhibition in vitro in cultures of human or Saimiri RBC. Although protective and inhibitory antibodies were detected in different Ig preparations, the levels of these activities were not directly correlated. Some Ig preparations, showing high protective activity, provide little or no inhibition of the parasite in vitro. Conversely, inhibitory activity was present in Ig preparations unable to confer protection in vivo. These results indicate that protective antibodies are active through a more complex immune mechanism than simple neutralization probably involving cellular immunity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
132
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
432-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
In vitro and in vivo studies on protective and inhibitory antibodies against Plasmodium falciparum in the Saimiri monkey.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't