Linked Life Data

6359324

Source:http://linkedlifedata.com/resource/pubmed/id/6359324

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-1-7
pubmed:abstractText
The variable regions of antibody molecules react with each other via specific recognition of clonally distributed antigenic determinants, known under the general term of idiotypes. The totality of such interactions determines a special behavior of the immune system, as a whole, and its ability to regulate immune responses has been analyzed by the 'immune network theory' of Jerne [5]. In light of this theory, a particular property of idiotypes appears to be of special interest: as revealed by recent experiments, frequently idiotype-like determinants represent internal images of antigens. These internal images can be topochemical copies of nominal non-self antigenic determinants, of various functional non-lymphoid receptors, or of transplantation antigens. In this article, we present a view according to which internal images are essential structures which mediate cellular interactions leading to the selection and conservation of the immune repertoire of T and B lymphocytes. Our opinion is exposed in the context of experimental data obtained in several laboratories, including ours.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0252-9564
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
78-87
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Internal images of antigens within the immune network.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Review